What are NITYR® (nitisinone) Tablets?

NITYR is here for you, for life

NITYR is an FDA-approved tablet indicated for the treatment of adult and pediatric patients with Tyrosinemia Type 1 (HT-1) in combination with dietary restriction of tyrosine and phenylalanine.

It is the same nitisinone you may be familiar with and is bioequivalent to Orfadin®** (nitisinone) capsules.1 Whilst it is bioequivalent, it is smaller than Orfadin®** capsules, doesn’t have any refrigeration restirctons and can be taken with or without food.2,3

We know that supporting people with rare diseases is about more than just the medicine. That’s why we created Cycle Vita™, delivering individualized product support* with NITYR, every step of the way.

Find out more about Cycle Vita

Flexible administration for all ages

  • Very small and discreet2
  • Baby aspirin-sized: 20% the volume of a single Orfadin®** (nitisinone) capsule2
  • NITYR is suitable for all age groups. It can be given as a suspension, crushed and mixed with applesauce, or swallowed whole
  • No refrigeration restrictions
  • Can be taken with or without food3
  • Makes NITYR easy to take on the go
  • Bioequivalent to Orfadin®** (nitisinone) capsules1
  • Same efficacy, same safety and same side effects as Orfadin®1
  • Uninterrupted, rapid supply of treatment
  • Insurance coverage and financial assistance with $0 co-pay for eligible patients*
  • Education resources, information and tools
  • Patient Nutrition Program*
NITYR®
Orfadin®**

Tablet and capsule not actual size

Data on file: REF-00041

Mother teaching daughter to read sitting at home on sofa

Download our Consultation Guide

Speak to your doctor about NITYR today. Our Consultation Guide will help you get the most of your discussion.

Consultation Guide

Taking NITYR

  1. Use the reusable syringe provided. Remove the plunger, add one NITYR tablet and replace the plunger.
  2. Draw up 2.6 mL of room temperature water.
  3. Put the cap back on. If you are using the 2 mg tablet(s), let the syringe sit for at least 15 minutes. If you are using the 5 mg or 10 mg tablet(s), let the syringe sit for at least 60 minutes.
  4. Once you are ready to administer (you can administer up to 24 hours after adding water to the tablet), turn the oral syringe up and down for at least 30 seconds and check that no large lumps of tablet remain. If there are large lumps, let the syringe sit for a further 10 minutes, and then reinspect the syringe for any large lumps. Once no large lumps of tablet remain, turn the oral syringe up and down for at least 30 seconds before administering the medication.
  5. Take the cap off, place the syringe in the child’s mouth, and push down on the plunger until a small amount of air remains in the syringe. Do not press the plunger all the way to the end.
  6. Rinse the syringe by drawing up another 2 mL of water. Replace the cap and shake the syringe well.
  7. Take the cap off, place the syringe in the child’s mouth and push down on the plunger until it is completely empty.

Step 1

Use the reusable syringe provided. Remove the plunger, add one NITYR tablet and replace the plunger

Step 2

Draw up 2.6 mL of room temperature water

Step 3

Put the cap back on and let the syringe sit for at least 60 minutes

Step 4

Once you are ready to administer (you can administer up to 24 hours after adding water to the tablet), turn the oral syringe up and down for at least 30 seconds and check that no large lumps of tablet remain. If there are large lumps, let the syringe sit for a further 10 minutes, and then reinspect the syringe for any large lumps. Once no large lumps of tablet remain, turn the oral syringe up and down for at least 30 seconds before administering the medication

Step 5

Take the cap off, place the syringe in the child’s mouth, and push down on the plunger until a small amount of air remains in the syringe. Do not press the plunger all the way to the end

Step 6

Rinse the syringe by drawing up another 2 mL of water. Replace the cap and shake the syringe well

Step 7

Take the cap off, place the syringe in the child’s mouth, and push down on the plunger until a small amount of air remains in the syringe. Do not press the plunger all the way to the end

"It is so simple. The water does the job."

Sana: Mom of Alina
(NITYR patient, 1 year old)

Instruction videoInstructions for useGet started with NITYR now

For further support or to receive additional oral syringes, please call Cycle Vita on 888-360-8482

Follow the same instructions for How to Give One NITYR Tablet Using an Oral Syringe, except:

  • In step 1, remove the plunger from the syringe and insert two tablets, then replace the plunger and
  • In step 2, draw up 5 mL of water at room temperature.

Step 1

Remove the plunger from the syringe and insert two tablets, then replace the plunger

Step 2

Draw up 5 mL of room temperature water
Information Icon
Note: More than two tablets should NOT be prepared in the same syringe.

If your healthcare provider advises you to give three tablets, follow the instructions to prepare one syringe with one tablet and another syringe with two tablets. The same instructions apply to more than three tablets.

Instructions for useGet started with NITYR now

For further support or to receive additional oral syringes, please call Cycle Vita on 888-360-8482

  1. Crush one NITYR tablet at a time by placing it between two teaspoons and pushing down lightly on the top spoon. Press, rotate, and look at the tablet. If large particles are still there, repeat until finely crushed.
  2. Add all the crushed tablet powder to one full teaspoon of applesauce in a clean glass or bowl.
  3. If giving more than one tablet, repeat the process above, adding the powder to the same applesauce.
  4. Mix well.
  5. Feed the mixture to your child using a teaspoon.
  6. To make sure you give your child all the medicine, add another full teaspoon of applesauce to the same glass or bowl and stir. Again, feed the mixture to your child.
  7. Use the NITYR-applesauce mixture within two hours of preparation.

Step 1

Crush one NITYR tablet at a time by placing it between two teaspoons and pushing down lightly on the top spoon. Press, rotate, and look at the tablet. If large particles are still there, repeat until finely crushed

Step 2

Add all the crushed tablet powder to one full teaspoon of applesauce in a clean glass or bowl

Step 3

If giving more than one tablet, repeat the process above, adding the powder to the same applesauce

Step 4

Mix well

Step 5

Feed the mixture to your child using a teaspoon

Step 6

Use the NITYR-applesauce mixture within two hours of preparation
Instructions for useGet started with NITYR now

For further support or to receive a tablet crusher, please call Cycle Vita on 888-360-8482

Cycle Vita Logo With Strapline
A friendly, familiar team is waiting here at Cycle Vita, for you, at every step.
Cycle Vita Logo With Strapline
A friendly, familiar team is waiting here at Cycle Vita, for you, at every step.

+1 (888) 360-8482

* Some areas of support may not be accessible to all patients. Eligibility criteria may apply to ensure compliance with all applicable federal and state requirements,  and benefits may be limited to commercially insured patients only. For more detailed information about eligibility, terms and conditions, please contact the Cycle Vita team at 888-360-8482.
** Orfadin is a registered trademark, licensed by Swedish Orphan Biovitrum AB (publ) and is marketed by Sobi, Inc.

References

1. Data on file REF-00047
2. Data on file: REF-00041
3. NITYR (nitisinone) Tablets. Prescribing Information. Cycle Pharmaceuticals Ltd